The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration

The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration

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OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured click here in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.RESULT: The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the revlon colorstay lip liner plum age-related macular degeneration patient group than in the control group (p0.05).

CONCLUSION: The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.